Key to Alzheimer’s: Waste in Cells

In its December 28, 2010 edition (click here for full article), THE WALL STREET JOURNAL reported that Researchers are trying different approaches to target the lysosome as a possible treatment for Alzheimer’s and other diseases.  Dr. Yiannis Ioannou of Mt. Sinai in New York, one of the principal investigators for SOAR-NPC, the treatment collaborative of which DART is a part, is cited among the researchers.  “At the Mount Sinai School of Medicine in New York, researchers led by Yiannis A. Ioannou have been studying cyclodextrin, a compound that has extended the lives of mice with a lysosomal storage disorder called Niemann-Pick Type C (NPC). Although the exact mechanism for this effect isn’t fully understood, Dr. Ioannou argues that the substance may work by stimulating the lysosomes in the mice neurons to dump out all of the stored waste products at once. This could be helpful for other neurodegenerative disorders that also have lysosomal involvement, he says…. Understanding how this works may make it easier to develop drugs that may help not only patients with NPC disease but a number of other neurodegenerative disorders, Dr. Ioannou says.”